The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells

Jinqiang Zhang; Chang Han; Kyoungsub Song; Weina Chen; Nathan Ungerleider; Lu Yao; Wenbo Ma; Tong Wu

doi:10.1371/journal.pone.0228160

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Open Access

Peer-reviewed

Research Article

The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells

Jinqiang Zhang,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Chang Han,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Kyoungsub Song,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Weina Chen,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Nathan Ungerleider,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Lu Yao,

Roles Resources

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Wenbo Ma,

Roles Investigation

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯
Tong Wu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Writing – review & editing

* E-mail: twu@tulane.edu

Affiliation Department of Pathology and Laboratory Medicine, Tulane, Wenbo University School of Medicine, New Orleans, Louisiana, United States of America
⨯

The long-noncoding RNA MALAT1 regulates TGF-β/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells

Jinqiang Zhang,
Chang Han,
Kyoungsub Song,
Weina Chen,
Nathan Ungerleider,
Lu Yao,
Wenbo Ma,
Tong Wu

Published: January 29, 2020
https://doi.org/10.1371/journal.pone.0228160

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Immunoprecipitation
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SMAD signaling
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Long non-coding RNA
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Small interfering RNA
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Hepatocytes
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Cell differentiation
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Transfection
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