Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies

Sumaira Javaid; Syed Muhammad Saad; Humaira Zafar; Rizwana Malik; Khalid Mohammed Khan; M. Iqbal Choudhary; Atta-ur Rahman

doi:10.1371/journal.pone.0227549

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Research Article

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies

Sumaira Javaid ,

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Writing – original draft, Writing – review & editing

* E-mail: sumairajavaid17@yahoo.com (SJ); khalid.khan@iccs.edu (KMK)

Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

http://orcid.org/0000-0002-6422-3022

⨯
Syed Muhammad Saad ,

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations H. E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, Department of Chemistry, University of Karachi, Karachi, Pakistan
⨯
Humaira Zafar ,

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
⨯
Rizwana Malik ,

Roles Methodology

¶‡ These authors also contributed equally to this work.

Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
⨯
Khalid Mohammed Khan ,

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: sumairajavaid17@yahoo.com (SJ); khalid.khan@iccs.edu (KMK)

Affiliations H. E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, Department of Clinical Pharmacy, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia
⨯
M. Iqbal Choudhary ,

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliations Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, H. E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
⨯
Atta-ur Rahman

Contributed equally to this work with: Sumaira Javaid, Syed Muhammad Saad, Humaira Zafar, Khalid Mohammed Khan, M. Iqbal Choudhary, Atta-ur Rahman

Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, H. E. J., Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
⨯

Thymidine phosphorylase and prostrate cancer cell proliferation inhibitory activities of synthetic 4-hydroxybenzohydrazides: In vitro, kinetic, and in silico studies

Sumaira Javaid,
Syed Muhammad Saad,
Humaira Zafar,
Rizwana Malik,
Khalid Mohammed Khan,
M. Iqbal Choudhary,
Atta-ur Rahman

Published: January 27, 2020
https://doi.org/10.1371/journal.pone.0227549

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