Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

Devorah M. Natelson; Alon Lai; Divya Krishnamoorthy; Robert C. Hoy; James C. Iatridis; Svenja Illien-Jünger

doi:10.1371/journal.pone.0227527

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Open Access

Peer-reviewed

Research Article

Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

Devorah M. Natelson,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Alon Lai,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Divya Krishnamoorthy,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Robert C. Hoy,

Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
James C. Iatridis,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

http://orcid.org/0000-0002-2186-0590

⨯
Svenja Illien-Jünger

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft

* E-mail: svenja.illien-junger@emory.edu

Affiliations Department of Orthopaedics, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America, Department of Orthopaedics, Emory University School of Medicine, Atlanta, GA, United States of America

http://orcid.org/0000-0001-9895-0693

⨯

Leptin signaling and the intervertebral disc: Sex dependent effects of leptin receptor deficiency and Western diet on the spine in a type 2 diabetes mouse model

Devorah M. Natelson,
Alon Lai,
Divya Krishnamoorthy,
Robert C. Hoy,
James C. Iatridis,
Svenja Illien-Jünger

Published: May 6, 2020
https://doi.org/10.1371/journal.pone.0227527

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Leptin
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Diabetes mellitus
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Mouse models
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Obesity
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Diet
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HbA1c
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Type 2 diabetes
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Bone density
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