Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

• Nhi Hin ,

  Contributed equally to this work with: Nhi Hin, Morgan Newman

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia, Alzheimer’s Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

  http://orcid.org/0000-0003-3063-4058

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• Morgan Newman ,

  Contributed equally to this work with: Nhi Hin, Morgan Newman

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Alzheimer’s Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

  http://orcid.org/0000-0002-4930-4529

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• Jan Kaslin,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

  ⨯
• Alon M. Douek,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Australian Regenerative Medicine Institute, Monash University, Clayton, Victoria, Australia

  http://orcid.org/0000-0001-5739-3835

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• Amanda Lumsden,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation College of Medicine and Public Health, and Centre for Neuroscience, Flinders University, Adelaide, South Australia, Australia

  ⨯
• Seyed Hani Moussavi Nik,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

  ⨯
• Yang Dong,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

  http://orcid.org/0000-0002-4810-2730

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• Xin-Fu Zhou,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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• Noralyn B. Mañucat-Tan,

  Roles Writing – review & editing

  Affiliation School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia

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• Alastair Ludington,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

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• David L. Adelson,

  Roles Conceptualization, Resources, Software, Supervision, Writing – review & editing

  Affiliation Centre for Bioinformatics and Computational Genetics, School of Bioogical Sciences, Adelaide, South Australia, Australia

  http://orcid.org/0000-0003-2404-5636

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• Stephen Pederson ,

  Roles Conceptualization, Formal analysis, Investigation, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors also contributed equally to this work.

  Affiliation Bioinformatics Hub, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

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• Michael Lardelli

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: michael.lardelli@adelaide.edu.au

  ¶‡ These authors also contributed equally to this work.

  Affiliation Alzheimer’s Disease Genetics Laboratory, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

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