Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

Kendra D. Maclaine; Kevin A. Stebbings; Daniel A. Llano; Justin S. Rhodes

doi:10.1371/journal.pone.0226860

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Open Access

Peer-reviewed

Research Article

Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

Kendra D. Maclaine ,

Contributed equally to this work with: Kendra D. Maclaine, Kevin A. Stebbings

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing

Affiliation Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America

http://orcid.org/0000-0003-0750-6365

⨯
Kevin A. Stebbings ,

Contributed equally to this work with: Kendra D. Maclaine, Kevin A. Stebbings

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliations Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Neuroscience Program, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Daniel A. Llano,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliations Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Neuroscience Program, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America
⨯
Justin S. Rhodes

Roles Formal analysis, Resources, Supervision, Writing – review & editing

* E-mail: jrhodes@illinois.edu

Affiliations Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Neuroscience Program, Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, United States of America, Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, Illinois, United States of America
⨯

Voluntary wheel running has no impact on brain and liver mitochondrial DNA copy number or mutation measures in the PolG mouse model of aging

Kendra D. Maclaine,
Kevin A. Stebbings,
Daniel A. Llano,
Justin S. Rhodes

Published: March 2, 2020
https://doi.org/10.1371/journal.pone.0226860
See the preprint

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Mitochondrial DNA
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Running
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Spleen
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Sedentary behavior
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Mammalian genomics
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Mouse models
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Mitochondria
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Homozygosity
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