The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

Esther Tijchon; Guoqiang Yi; Amit Mandoli; Jos G. A. Smits; Francesco Ferrari; Branco M. H. Heuts; Falco Wijnen; Bowon Kim; Eva M. Janssen-Megens; Jan Jacob Schuringa; Joost H. A. Martens

doi:10.1371/journal.pone.0226435

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Open Access

Peer-reviewed

Research Article

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

Esther Tijchon,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Guoqiang Yi,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Amit Mandoli,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Visualization

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Jos G. A. Smits,

Roles Data curation, Formal analysis, Investigation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Francesco Ferrari,

Roles Data curation, Formal analysis, Investigation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Branco M. H. Heuts,

Roles Data curation, Formal analysis, Validation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Falco Wijnen,

Roles Data curation, Investigation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Bowon Kim,

Roles Formal analysis, Investigation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Eva M. Janssen-Megens,

Roles Data curation, Formal analysis, Investigation

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands
⨯
Jan Jacob Schuringa,

Roles Formal analysis, Investigation

Affiliation Department of Hematology, University Medical Centre Groningen, Groningen, The Netherlands
⨯
Joost H. A. Martens

Roles Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: j.martens@ncmls.ru.nl

Affiliation Radboud University, Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Nijmegen, the Netherlands

http://orcid.org/0000-0003-2008-6537

⨯

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

Esther Tijchon,
Guoqiang Yi,
Amit Mandoli,
Jos G. A. Smits,
Francesco Ferrari,
Branco M. H. Heuts,
Falco Wijnen,
Bowon Kim,
Eva M. Janssen-Megens,
Jan Jacob Schuringa

Published: December 23, 2019
https://doi.org/10.1371/journal.pone.0226435

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Cell differentiation
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Induced pluripotent stem cells
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Granulocytes
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Gene expression
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Acute myeloid leukemia
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Monocytes
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