Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)

Jie Liu; Weiwei Zhao; Xiaohua Ou; Zhen Zhao; Changming Hu; Mingming Sun; Feifei Liu; Junhao Deng; Weili Gu; Jiaying An; Qingling Zhang; Xiaoxian Zhang; Jiaxing Xie; Shiyue Li; Rongchang Chen; Shihui Yu; Nanshan Zhong

doi:10.1371/journal.pone.0226400

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Open Access

Peer-reviewed

Research Article

Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)

Jie Liu ,

Contributed equally to this work with: Jie Liu, Weiwei Zhao

Roles Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong, China, National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China
⨯
Weiwei Zhao ,

Contributed equally to this work with: Jie Liu, Weiwei Zhao

Roles Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliations Guangzhou KingMed Diagnostics Group Co., Ltd, Guangzhou, Guangdong, China, Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China
⨯
Xiaohua Ou,

Roles Formal analysis, Methodology, Validation, Writing – original draft

Affiliations Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China
⨯
Zhen Zhao,

Roles Methodology

Affiliations Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China
⨯
Changming Hu,

Roles Supervision

Affiliation Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China
⨯
Mingming Sun,

Roles Data curation, Software

Affiliations Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China
⨯
Feifei Liu,

Roles Project administration

Affiliations Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China
⨯
Junhao Deng,

Roles Software, Visualization

Affiliation Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China
⨯
Weili Gu,

Roles Project administration

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China
⨯
Jiaying An,

Roles Investigation

Affiliation Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China
⨯
Qingling Zhang,

Roles Investigation

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong, China, National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China
⨯
Xiaoxian Zhang,

Roles Project administration

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China
⨯
Jiaxing Xie,

Roles Investigation

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong, China, National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China
⨯
Shiyue Li,

Roles Investigation

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong, China, National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China
⨯
Rongchang Chen,

Roles Supervision

Affiliation Department of Pulmonary and Critical Care Medicine, Shenzhen People's Hospital, Shenzhen, Guangdong, China
⨯
Shihui Yu ,

Roles Conceptualization, Funding acquisition, Writing – review & editing

* E-mail: zb-yushihui@kingmed.com.cn (SY); nanshan@vip.163.com (NZ)

¶‡ These authors also contributed equally to this work.

Affiliations Guangzhou KingMed Diagnostics Group Co., Ltd, Guangzhou, Guangdong, China, Clinical Genome Center, KingMed Center for Clinical Laboratory Co., Ltd, Guangzhou, Guangdong, China, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou KingMed Translational Medicine Institute Co., Ltd, Guangzhou, Guangdong, China, KingMed JianShi Innovation Institute (Guangzhou) Co., Ltd, Guangzhou, Guangdong, China

http://orcid.org/0000-0003-3672-4732

⨯
[ ... ],
Nanshan Zhong

Roles Conceptualization, Writing – review & editing

* E-mail: zb-yushihui@kingmed.com.cn (SY); nanshan@vip.163.com (NZ)

¶‡ These authors also contributed equally to this work.

Affiliations Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China, Guangzhou Institute for Respiratory Health, Guangzhou, Guangdong, China, State Key Laboratory of Respiratory Diseases, Guangzhou, Guangdong, China, National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China
⨯
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Mutation spectrums of TSC1 and TSC2 in Chinese women with lymphangioleiomyomatosis (LAM)

Jie Liu,
Weiwei Zhao,
Xiaohua Ou,
Zhen Zhao,
Changming Hu,
Mingming Sun,
Feifei Liu,
Junhao Deng,
Weili Gu,
Jiaying An

Published: December 19, 2019
https://doi.org/10.1371/journal.pone.0226400

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