Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Ci-Di Chen; Yuexuan Li; Arthur K. Chen; Melissa A. Rudy; Jason S. Nasse; Ella Zeldich; Taryn J. Polanco; Carmela R. Abraham

doi:10.1371/journal.pone.0226382

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Open Access

Peer-reviewed

Research Article

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Ci-Di Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Yuexuan Li ,

Contributed equally to this work with: Yuexuan Li, Arthur K. Chen, Melissa A. Rudy

Roles Data curation

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Arthur K. Chen ,

Contributed equally to this work with: Yuexuan Li, Arthur K. Chen, Melissa A. Rudy

Roles Data curation

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Melissa A. Rudy ,

Contributed equally to this work with: Yuexuan Li, Arthur K. Chen, Melissa A. Rudy

Roles Data curation

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Jason S. Nasse,

Roles Data curation

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Ella Zeldich,

Roles Data curation, Formal analysis

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Taryn J. Polanco,

Roles Data curation

Affiliation Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
⨯
Carmela R. Abraham

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: cabraham@bu.edu

Affiliations Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-6649-1960

⨯

Identification of the cleavage sites leading to the shed forms of human and mouse anti-aging and cognition-enhancing protein Klotho

Ci-Di Chen,
Yuexuan Li,
Arthur K. Chen,
Melissa A. Rudy,
Jason S. Nasse,
Ella Zeldich,
Taryn J. Polanco,
Carmela R. Abraham

Published: January 13, 2020
https://doi.org/10.1371/journal.pone.0226382

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