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Open Access

Peer-reviewed

Research Article

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4⁺CD45RB^high T cells

Kyoko Shimano,

Roles Investigation, Visualization, Writing – original draft

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Yasuhiro Maeda,

Roles Investigation, Visualization

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Hirotoshi Kataoka,

Roles Investigation

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Mikako Murase,

Roles Investigation

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Sachiko Mochizuki,

Roles Investigation

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Hiroyuki Utsumi,

Roles Investigation

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Koichi Oshita,

Roles Supervision

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan
⨯
Kunio Sugahara

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: Sugahara.Kunio@me.mt-pharma.co.jp

Affiliation Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

http://orcid.org/0000-0002-5782-4540

⨯

Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4⁺CD45RB^high T cells

Kyoko Shimano,
Yasuhiro Maeda,
Hirotoshi Kataoka,
Mikako Murase,
Sachiko Mochizuki,
Hiroyuki Utsumi,
Koichi Oshita,
Kunio Sugahara

x

Published: December 5, 2019
https://doi.org/10.1371/journal.pone.0226154

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Colitis
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T cells
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Colon
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Lymphocytes
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T helper cells
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Mouse models
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T cell receptors
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Adoptive transfer
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