Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Mereena George Ushakumary; Mingyi Wang; Harikrishnan V; Allen Sam Titus; Jing Zhang; Lijuan Liu; Robert Monticone; Yushi Wang; Julie A. Mattison; Rafael de Cabo; Edward G. Lakatta; Shivakumar Kailasam

doi:10.1371/journal.pone.0225911

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Peer-reviewed

Research Article

Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Mereena George Ushakumary ,

Contributed equally to this work with: Mereena George Ushakumary, Mingyi Wang, Harikrishnan V

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
⨯
Mingyi Wang ,

Contributed equally to this work with: Mereena George Ushakumary, Mingyi Wang, Harikrishnan V

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Harikrishnan V ,

Contributed equally to this work with: Mereena George Ushakumary, Mingyi Wang, Harikrishnan V

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
⨯
Allen Sam Titus ,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

¶‡ These authors also contributed equally to this work

Affiliation Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India
⨯
Jing Zhang ,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Lijuan Liu ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Robert Monticone ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Yushi Wang ,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliations Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America, Department of Cardiology, The First Hospital of Jilin University, Changchun, China
⨯
Julie A. Mattison ,

Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliation Translational Gerontology Branch, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Rafael de Cabo ,

Roles Formal analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization

¶‡ These authors also contributed equally to this work

Affiliation Translational Gerontology Branch, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Edward G. Lakatta ,

Roles Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization

* E-mail: shivak@sctimst.ac.in (SK); lakattae@grc.nia.nih.gov (EGL)

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institute on Aging/National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Shivakumar Kailasam

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: shivak@sctimst.ac.in (SK); lakattae@grc.nia.nih.gov (EGL)

Affiliation Division of Cellular and Molecular Cardiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India

http://orcid.org/0000-0002-5129-4913

⨯

Discoidin domain Receptor 2: A determinant of metabolic syndrome-associated arterial fibrosis in non-human primates

Mereena George Ushakumary,
Mingyi Wang,
Harikrishnan V,
Allen Sam Titus,
Jing Zhang,
Lijuan Liu,
Robert Monticone,
Yushi Wang,
Julie A. Mattison,
Rafael de Cabo

Published: December 5, 2019
https://doi.org/10.1371/journal.pone.0225911

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