Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Ravi K. Patel; Mark C. Weir; Kexin Shen; Daniel Snyder; Vaughn S. Cooper; Thomas E. Smithgall

doi:10.1371/journal.pone.0225887

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Peer-reviewed

Research Article

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Ravi K. Patel,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Mark C. Weir,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Kexin Shen,

Roles Investigation, Methodology, Validation, Writing – review & editing

Current address: Tsinghua University School of Medicine, Beijing, China

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Daniel Snyder,

Roles Formal analysis, Investigation, Methodology, Software, Validation

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Vaughn S. Cooper,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-7726-0765

⨯
Thomas E. Smithgall

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: tsmithga@pitt.edu

Affiliation Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-5238-3806

⨯

Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance

Ravi K. Patel,
Mark C. Weir,
Kexin Shen,
Daniel Snyder,
Vaughn S. Cooper,
Thomas E. Smithgall

Published: December 2, 2019
https://doi.org/10.1371/journal.pone.0225887

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Tyrosine kinases
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Acute myeloid leukemia
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In vitro kinase assay
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Point mutation
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Kinase inhibitors
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