A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice

Sven Wolfgang Görgens; Kerstin Jahn-Hofmann; Dinesh Bangari; Sheila Cummings; Christiane Metz-Weidmann; Uwe Schwahn; Paulus Wohlfart; Matthias Schäfer; Maximilian Bielohuby

doi:10.1371/journal.pone.0225835

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Open Access

Peer-reviewed

Research Article

A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice

Sven Wolfgang Görgens,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany

http://orcid.org/0000-0002-5676-3731

⨯
Kerstin Jahn-Hofmann,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany
⨯
Dinesh Bangari,

Roles Conceptualization, Formal analysis, Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Sanofi, Global Discovery Pathology, Translational In-vivo Models Framingham, MA, United States of America
⨯
Sheila Cummings,

Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Sanofi, Global Discovery Pathology, Translational In-vivo Models Framingham, MA, United States of America

http://orcid.org/0000-0001-5221-499X

⨯
Christiane Metz-Weidmann,

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany
⨯
Uwe Schwahn,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany
⨯
Paulus Wohlfart ,

Roles Data curation, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: paulus.wohlfart@sanofi.com (PW); maximilian.bielohuby@sanofi.com (MB)

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany

http://orcid.org/0000-0002-0986-5911

⨯
Matthias Schäfer,

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany
⨯
Maximilian Bielohuby

Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: paulus.wohlfart@sanofi.com (PW); maximilian.bielohuby@sanofi.com (MB)

Affiliation Sanofi-Aventis Deutschland GmbH, Industriepark Hoechst, Frankfurt am Main, Germany
⨯

A siRNA mediated hepatic dpp4 knockdown affects lipid, but not glucose metabolism in diabetic mice

Sven Wolfgang Görgens,
Kerstin Jahn-Hofmann,
Dinesh Bangari,
Sheila Cummings,
Christiane Metz-Weidmann,
Uwe Schwahn,
Paulus Wohlfart,
Matthias Schäfer,
Maximilian Bielohuby

Published: December 3, 2019
https://doi.org/10.1371/journal.pone.0225835

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