Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD)

Robin C. Su; Apurva Lad; Joshua D. Breidenbach; Thomas M. Blomquist; William T. Gunning; Prabhatchandra Dube; Andrew L. Kleinhenz; Deepak Malhotra; Steven T. Haller; David J. Kennedy

doi:10.1371/journal.pone.0225604

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Open Access

Peer-reviewed

Research Article

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Lepr^db/J mouse model of non-alcoholic fatty liver disease (NAFLD)

Robin C. Su,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America

http://orcid.org/0000-0002-7423-0939

⨯
Apurva Lad,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
Joshua D. Breidenbach,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America

http://orcid.org/0000-0002-5892-1879

⨯
Thomas M. Blomquist,

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization

Affiliation Department of Pathology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
William T. Gunning,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliation Department of Pathology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
Prabhatchandra Dube,

Roles Data curation, Investigation, Software

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
Andrew L. Kleinhenz,

Roles Data curation, Methodology, Resources, Software, Writing – review & editing

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
Deepak Malhotra,

Roles Project administration

Affiliation Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
Steven T. Haller ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: David.Kennedy@UToledo.edu (DK); Steven.Haller@UToledo.edu (SH)

Affiliations Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America, Department of Medical Microbiology and Immunology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯
David J. Kennedy

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: David.Kennedy@UToledo.edu (DK); Steven.Haller@UToledo.edu (SH)

Affiliations Department of Medicine, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America, Department of Medical Microbiology and Immunology, The University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, United States of America
⨯

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Lepr^db/J mouse model of non-alcoholic fatty liver disease (NAFLD)

Robin C. Su,
Apurva Lad,
Joshua D. Breidenbach,
Thomas M. Blomquist,
William T. Gunning,
Prabhatchandra Dube,
Andrew L. Kleinhenz,
Deepak Malhotra,
Steven T. Haller,
David J. Kennedy

Published: December 5, 2019
https://doi.org/10.1371/journal.pone.0225604

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