A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma

Anna Minchom; Daisy Mak; Ranga Gunapala; David Walder; Rajiv Kumar; Nadia Yousaf; Andrew Hodgkiss; Jaishree Bhosle; Sanjay Popat; Mary E. R. O’Brien

doi:10.1371/journal.pone.0225509

Loading metrics

Open Access

Peer-reviewed

Research Article

A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma

Anna Minchom ,

Contributed equally to this work with: Anna Minchom, Daisy Mak

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
Daisy Mak ,

Contributed equally to this work with: Anna Minchom, Daisy Mak

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom

http://orcid.org/0000-0002-0493-6565

⨯
Ranga Gunapala,

Roles Data curation, Formal analysis

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
David Walder,

Roles Investigation

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
Rajiv Kumar,

Roles Investigation

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
Nadia Yousaf,

Roles Investigation

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Andrew Hodgkiss,

Roles Investigation, Methodology

Affiliation Adult Psychological Support Service, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
Jaishree Bhosle,

Roles Investigation

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯
Sanjay Popat,

Roles Investigation

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, London, United Kingdom
⨯
Mary E. R. O’Brien

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: mary.obrien@rmh.nhs.uk

Affiliation Lung Cancer Unit, Royal Marsden NHS Foundation Trust, Sutton, United Kingdom
⨯

A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma

Anna Minchom,
Daisy Mak,
Ranga Gunapala,
David Walder,
Rajiv Kumar,
Nadia Yousaf,
Andrew Hodgkiss,
Jaishree Bhosle,
Sanjay Popat,
Mary E. R. O’Brien

Published: November 25, 2019
https://doi.org/10.1371/journal.pone.0225509

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Cobalamins
Is the Subject Area "Cobalamins" applicable to this article?

Thanks for your feedback.
Vitamins
Is the Subject Area "Vitamins" applicable to this article?

Thanks for your feedback.
Chemotherapy
Is the Subject Area "Chemotherapy" applicable to this article?

Thanks for your feedback.
Folic acid
Is the Subject Area "Folic acid" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Drug therapy
Is the Subject Area "Drug therapy" applicable to this article?

Thanks for your feedback.
Depression
Is the Subject Area "Depression" applicable to this article?

Thanks for your feedback.