Drugs modulating stochastic gene expression affect the erythroid differentiation process

Anissa Guillemin; Ronan Duchesne; Fabien Crauste; Sandrine Gonin-Giraud; Olivier Gandrillon

doi:10.1371/journal.pone.0225166

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Open Access

Peer-reviewed

Research Article

Drugs modulating stochastic gene expression affect the erythroid differentiation process

Anissa Guillemin,

Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Laboratoire de biologie et modélisation de la cellule. LBMC - Ecole Normale Supérieure - Lyon, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique: UMR5239, Institut National de la Santé et de la Recherche Médicale: U1210 - Ecole Normale Supérieure de Lyon 46 allée d’Italie 69007 Lyon, France

http://orcid.org/0000-0002-7989-200X

⨯
Ronan Duchesne,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Laboratoire de biologie et modélisation de la cellule. LBMC - Ecole Normale Supérieure - Lyon, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique: UMR5239, Institut National de la Santé et de la Recherche Médicale: U1210 - Ecole Normale Supérieure de Lyon 46 allée d’Italie 69007 Lyon, France, Inria Dracula, Villeurbanne, France
⨯
Fabien Crauste,

Roles Supervision, Writing – review & editing

Affiliations Inria Dracula, Villeurbanne, France, Univ. Bordeaux, CNRS, Bordeaux INP, IMB, UMR 5251, F-33400, Talence, France
⨯
Sandrine Gonin-Giraud,

Roles Supervision, Writing – review & editing

Affiliation Laboratoire de biologie et modélisation de la cellule. LBMC - Ecole Normale Supérieure - Lyon, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique: UMR5239, Institut National de la Santé et de la Recherche Médicale: U1210 - Ecole Normale Supérieure de Lyon 46 allée d’Italie 69007 Lyon, France
⨯
Olivier Gandrillon

Roles Supervision, Writing – review & editing

* E-mail: olivier.gandrillon@ens-lyon.fr

Affiliations Laboratoire de biologie et modélisation de la cellule. LBMC - Ecole Normale Supérieure - Lyon, Université Claude Bernard Lyon 1, Centre National de la Recherche Scientifique: UMR5239, Institut National de la Santé et de la Recherche Médicale: U1210 - Ecole Normale Supérieure de Lyon 46 allée d’Italie 69007 Lyon, France, Inria Dracula, Villeurbanne, France
⨯

Drugs modulating stochastic gene expression affect the erythroid differentiation process

Anissa Guillemin,
Ronan Duchesne,
Fabien Crauste,
Sandrine Gonin-Giraud,
Olivier Gandrillon

Published: November 21, 2019
https://doi.org/10.1371/journal.pone.0225166
See the preprint

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Cell differentiation
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Artemisinin
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Gene expression
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Kullback Leibler divergence
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