Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar; Victoria Korboukh; Leslie C. Conway; Heike J. Wobst; Chandler A. Walker; Peter Doig; Steve J. Jacobsen; Nicholas J. Brandon; Stephen J. Moss; Qi Wang

doi:10.1371/journal.pone.0225145

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Open Access

Peer-reviewed

Research Article

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar,

Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft

Affiliation AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America
⨯
Victoria Korboukh,

Roles Data curation, Investigation

Affiliation Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Leslie C. Conway,

Roles Data curation, Investigation

Affiliation AstraZeneca Tufts Laboratory for Basic and Translational Neuroscience, Tufts University, Boston, MA, United States of America
⨯
Heike J. Wobst,

Roles Data curation, Investigation

Affiliation Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Chandler A. Walker,

Roles Data curation, Investigation

Affiliation Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Peter Doig,

Roles Conceptualization

Affiliation Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Steve J. Jacobsen,

Roles Conceptualization, Funding acquisition

Affiliation Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Nicholas J. Brandon,

Roles Conceptualization

Affiliation Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America
⨯
Stephen J. Moss,

Roles Conceptualization, Supervision

Affiliations Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America, Department of Neuroscience, Tufts University School of Medicine, Boston, MA, United States of America, Department of Neuroscience, Physiology and Pharmacology, University College, London, United Kingdom
⨯
Qi Wang

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: qi.wang@azneuro.com

Affiliation Neuroscience, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, United States of America

http://orcid.org/0000-0002-5077-6304

⨯

Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells

Jayashree Chadchankar,
Victoria Korboukh,
Leslie C. Conway,
Heike J. Wobst,
Chandler A. Walker,
Peter Doig,
Steve J. Jacobsen,
Nicholas J. Brandon,
Stephen J. Moss,
Qi Wang

Published: November 8, 2019
https://doi.org/10.1371/journal.pone.0225145

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Proteasomes
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Immunoprecipitation
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Immunoblotting
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Ubiquitination
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