Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods

Aarti Gautam; Duncan Donohue; Allison Hoke; Stacy Ann Miller; Seshamalini Srinivasan; Bintu Sowe; Leanne Detwiler; Jesse Lynch; Michael Levangie; Rasha Hammamieh; Marti Jett

doi:10.1371/journal.pone.0225137

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Open Access

Peer-reviewed

Research Article

Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods

Aarti Gautam,

Roles Conceptualization, Investigation, Supervision, Writing – original draft

Affiliation US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America

http://orcid.org/0000-0003-3132-5599

⨯
Duncan Donohue,

Roles Formal analysis, Visualization

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, The Geneva Foundation, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Allison Hoke,

Roles Data curation, Methodology, Writing – review & editing

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, Oak Ridge Institute for Science and Education, Fort Detrick, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Stacy Ann Miller,

Roles Data curation, Methodology

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, Oak Ridge Institute for Science and Education, Fort Detrick, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Seshamalini Srinivasan,

Roles Data curation

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, The Geneva Foundation, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Bintu Sowe,

Roles Data curation

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, Oak Ridge Institute for Science and Education, Fort Detrick, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Leanne Detwiler,

Roles Methodology

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, The Geneva Foundation, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Jesse Lynch,

Roles Methodology

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, Oak Ridge Institute for Science and Education, Fort Detrick, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Michael Levangie,

Roles Methodology

Affiliations US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America, The Geneva Foundation, US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Rasha Hammamieh,

Roles Project administration

Affiliation US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯
Marti Jett

Roles Funding acquisition, Supervision

* E-mail: marti.jett-tilton.civ@mail.mil

Affiliation US Army Center for Environmental Health Research, Fort Detrick, MD, United States of America
⨯

Investigating gene expression profiles of whole blood and peripheral blood mononuclear cells using multiple collection and processing methods

Aarti Gautam,
Duncan Donohue,
Allison Hoke,
Stacy Ann Miller,
Seshamalini Srinivasan,
Bintu Sowe,
Leanne Detwiler,
Jesse Lynch,
Michael Levangie,
Rasha Hammamieh

Published: December 6, 2019
https://doi.org/10.1371/journal.pone.0225137

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Blood
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Gene expression
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RNA extraction
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White blood cells
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Specimen storage
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T cells
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RNA isolation
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