A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling

• Jason S. Nagati ,

  Contributed equally to this work with: Jason S. Nagati, Min Xu

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

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• Min Xu ,

  Contributed equally to this work with: Jason S. Nagati, Min Xu

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Trent Garcia,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

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• Sarah A. Comerford,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Robert E. Hammer,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Joseph A. Garcia

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jag2369@cumc.columbia.edu

  Affiliations Department of Medicine, Columbia University Medical Center, New York, New York, United States of America, Department of Research, James J. Peters VA Medical Center, New York, New York, United States of America

  http://orcid.org/0000-0002-5621-7538

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