Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Minori Kubota; Kazuki Kakimoto; Takatoshi Nakagawa; Eiko Koubayashi; Kei Nakazawa; Hideki Tawa; Yuki Hirata; Toshihiko Okada; Ken Kawakami; Akira Asai; Shuhei Hosomi; Toshihisa Takeuchi; Shinya Fukunishi; Takuya Inoue; Michio Asahi; Kazuhide Higuchi

doi:10.1371/journal.pone.0225066

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Open Access

Peer-reviewed

Research Article

Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Minori Kubota ,

Contributed equally to this work with: Minori Kubota, Kazuki Kakimoto

Roles Formal analysis, Investigation, Methodology, Resources

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Kazuki Kakimoto ,

Contributed equally to this work with: Minori Kubota, Kazuki Kakimoto

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Takatoshi Nakagawa,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation

Affiliation Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Eiko Koubayashi,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Kei Nakazawa,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Hideki Tawa,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Yuki Hirata,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Toshihiko Okada,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Ken Kawakami,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Akira Asai,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Shuhei Hosomi,

Roles Investigation

Affiliation Department of Gastroenterology, Osaka City University Graduate School of Medicine, Asahimachi, Abeno-ku, Osaka, Japan
⨯
Toshihisa Takeuchi,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Shinya Fukunishi,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Takuya Inoue,

Roles Investigation

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
Michio Asahi ,

Roles Conceptualization, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: masahi@osaka-med.ac.jp (MA); higuchi@osaka-med.ac.jp (KH)

Affiliation Department of Pharmacology, Faculty of Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan

http://orcid.org/0000-0002-3139-6373

⨯
[ ... ],
Kazuhide Higuchi

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: masahi@osaka-med.ac.jp (MA); higuchi@osaka-med.ac.jp (KH)

Affiliation 2nd Department of Internal Medicine, Osaka Medical College, Daigakumachi, Takatsuki, Osaka, Japan
⨯
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Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Minori Kubota,
Kazuki Kakimoto,
Takatoshi Nakagawa,
Eiko Koubayashi,
Kei Nakazawa,
Hideki Tawa,
Yuki Hirata,
Toshihiko Okada,
Ken Kawakami,
Akira Asai

Published: November 8, 2019
https://doi.org/10.1371/journal.pone.0225066

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Autophagic cell death
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Cytokines
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MAPK signaling cascades
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Colitis
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