Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies

• Sumaira Javaid ,

  Contributed equally to this work with: Sumaira Javaid, Muniza Shaikh

  Roles Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

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• Muniza Shaikh ,

  Contributed equally to this work with: Sumaira Javaid, Muniza Shaikh

  Roles Data curation, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

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• Narjis Fatima ,

  Roles Methodology

  ¶‡ These authors also contributed equally to this work.

  Affiliation Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

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• M. Iqbal Choudhary

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: iqbal.choudhary@iccs.edu

  ¶‡ These authors also contributed equally to this work.

  Affiliations Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center of Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan, Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah, Saudi Arabia

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