Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects

• Dustin K. Bauknight ,

  Contributed equally to this work with: Dustin K. Bauknight, Victoria Osinski

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America, Cancer Center, University of Virginia, Charlottesville, VA, United States of America

  http://orcid.org/0000-0002-1292-3297

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• Victoria Osinski ,

  Contributed equally to this work with: Dustin K. Bauknight, Victoria Osinski

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America, Department of Pathology, University of Virginia, Charlottesville, VA, United States of America

  http://orcid.org/0000-0002-8969-8454

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• Siva Sai Krishna Dasa,

  Roles Conceptualization, Formal analysis, Investigation, Methodology

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America, Cancer Center, University of Virginia, Charlottesville, VA, United States of America

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• Anh T. Nguyen,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America

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• Melissa A. Marshall,

  Roles Formal analysis, Investigation

  Affiliation Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America

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• Julia Hartman,

  Roles Formal analysis, Investigation

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America

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• Matthew Harms,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

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• Gavin O’Mahony,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliation Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden

  http://orcid.org/0000-0001-5944-1271

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• Jeremie Boucher,

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliations Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden, The Lundberg Laboratory for Diabetes Research, University of Gothenburg, Gothenburg, Sweden, Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden

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• Alexander L. Klibanov,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America, Department of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, United States of America

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• Coleen A. McNamara,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States of America, Department of Medicine, Division of Cardiovascular Medicine, University of Virginia, Charlottesville, VA, United States of America

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• Kimberly A. Kelly

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: kak3x@virginia.edu

  Affiliations Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States of America, Cancer Center, University of Virginia, Charlottesville, VA, United States of America

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