UM171 induces a homeostatic inflammatory-detoxification response supporting human HSC self-renewal

• Jalila Chagraoui,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Bernhard Lehnertz,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Simon Girard,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Jean Francois Spinella,

  Roles Data curation, Formal analysis, Methodology, Software, Writing – review & editing

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Iman Fares,

  Roles Formal analysis, Investigation

  Affiliation Department of Molecular, Cell and Developmental Biology, UCLA, LA, United States of America

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• Elisa Tomellini,

  Roles Formal analysis, Investigation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Nadine Mayotte,

  Roles Methodology, Validation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Sophie Corneau,

  Roles Validation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

  http://orcid.org/0000-0003-0408-3010

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• Tara MacRae,

  Roles Methodology, Validation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Laura Simon,

  Roles Validation

  Affiliation Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada

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• Guy Sauvageau

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: guy.sauvageau@umontreal.ca

  Affiliations Molecular Genetics of Stem Cells Laboratory, Institute for Research in Immunology and Cancer (IRIC), University of Montreal, Montreal, QC, Canada, Division of Hematology, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada, Department of Medicine, Faculty of Medicine, University de Montreal, Montreal, QC, Canada

  http://orcid.org/0000-0002-4333-7266

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