The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman; Roberto Romero; Adi L. Tarca; Percy Pacora; Brian Ingram; Eli Maymon; Tinnakorn Chaiworapongsa; Sonia S. Hassan; Offer Erez

doi:10.1371/journal.pone.0224682

Loading metrics

Open Access

Peer-reviewed

Research Article

The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, Michigan, United States of America
⨯
Roberto Romero ,

Roles Conceptualization, Investigation, Supervision, Writing – review & editing

* E-mail: prbchiefstaff@med.wayne.edu (RR); atarca@med.wayne.edu (ALT)

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, United States of America, Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, United States of America, Center for Molecular Medicine and Genetics, Wayne State University, Detroit, Michigan, United States of America, Detroit Medical Center, Detroit, Michigan, United States of America
⨯
Adi L. Tarca ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing

* E-mail: prbchiefstaff@med.wayne.edu (RR); atarca@med.wayne.edu (ALT)

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Computer Science, Wayne State University College of Engineering, Detroit, Michigan, United States of America

http://orcid.org/0000-0003-1712-7588

⨯
Percy Pacora,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Brian Ingram,

Roles Data curation, Methodology, Resources

Affiliation Metabolon Inc., Raleigh-Durham, North Carolina, United States of America
⨯
Eli Maymon,

Roles Investigation, Writing – review & editing

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
⨯
Tinnakorn Chaiworapongsa,

Roles Conceptualization, Data curation, Methodology

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Sonia S. Hassan,

Roles Investigation, Project administration, Resources

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Offer Erez

Roles Conceptualization, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliations Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD/NIH/DHHS), Bethesda, Maryland, and Detroit, Michigan, United States of America, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, United States of America, Maternity Department "D," Division of Obstetrics and Gynecology, Soroka University Medical Center, School of Medicine, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheva, Israel
⨯

The plasma metabolome of women in early pregnancy differs from that of non-pregnant women

Samuel K. Handelman,
Roberto Romero,
Adi L. Tarca,
Percy Pacora,
Brian Ingram,
Eli Maymon,
Tinnakorn Chaiworapongsa,
Sonia S. Hassan,
Offer Erez

Published: November 14, 2019
https://doi.org/10.1371/journal.pone.0224682

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Pregnancy
Is the Subject Area "Pregnancy" applicable to this article?

Thanks for your feedback.
Metabolites
Is the Subject Area "Metabolites" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.
Metabolic networks
Is the Subject Area "Metabolic networks" applicable to this article?

Thanks for your feedback.
Steroids
Is the Subject Area "Steroids" applicable to this article?

Thanks for your feedback.
Metabolomics
Is the Subject Area "Metabolomics" applicable to this article?

Thanks for your feedback.
Steroid hormones
Is the Subject Area "Steroid hormones" applicable to this article?

Thanks for your feedback.
Small molecules
Is the Subject Area "Small molecules" applicable to this article?

Thanks for your feedback.