Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

• Hans E. Hohmeier,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America, Division of Endocrinology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

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• Lu Zhang,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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• Brandon Taylor,

  Roles Conceptualization, Data curation, Formal analysis, Investigation

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Samuel Stephens,

  Roles Data curation, Investigation, Methodology

  Current address: Fraternal Order of Eagles Diabetes Center, Department of Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

  Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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• Danhong Lu,

  Roles Data curation, Investigation

  Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America

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• Peter McNamara,

  Roles Conceptualization, Project administration

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Bryan Laffitte,

  Roles Conceptualization, Funding acquisition, Investigation

  Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

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• Christopher B. Newgard

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: chris.newgard@duke.edu

  Affiliations Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America, Duke Molecular Physiology Institute, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, United States of America, Department of Medicine, Duke University Medical Center, Durham, North Carolina, United States of America

  http://orcid.org/0000-0002-1293-691X

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