Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation

Heather F. Sinner; Jeremy Johnson; Piotr G. Rychahou; David S. Watt; Yekaterina Y. Zaytseva; Chunming Liu; B. Mark Evers

doi:10.1371/journal.pone.0224253

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Open Access

Peer-reviewed

Research Article

Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation

Heather F. Sinner,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Jeremy Johnson,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Piotr G. Rychahou,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – review & editing

Affiliations Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David S. Watt,

Roles Resources, Writing – review & editing

Affiliations Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America, Center for Molecular Medicine, Organic Synthesis Core, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Yekaterina Y. Zaytseva,

Roles Resources, Writing – review & editing

Affiliations Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Chunming Liu,

Roles Resources, Writing – review & editing

Affiliations Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America, Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America
⨯
B. Mark Evers

Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

* E-mail: mark.evers@uky.edu

Affiliations Department of Surgery, University of Kentucky, Lexington, Kentucky, United States of America, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

http://orcid.org/0000-0002-9425-2342

⨯

Novel chemotherapeutic agent, FND-4b, activates AMPK and inhibits colorectal cancer cell proliferation

Heather F. Sinner,
Jeremy Johnson,
Piotr G. Rychahou,
David S. Watt,
Yekaterina Y. Zaytseva,
Chunming Liu,
B. Mark Evers

Published: October 24, 2019
https://doi.org/10.1371/journal.pone.0224253

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