Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome

Yosra Doghri; Fabien Chetaneau; Moez Rhimi; Aicha Kriaa; Valérie Lalanne; Chantal Thorin; Emmanuelle Maguin; M. Yassine Mallem; Jean-Claude Desfontis

doi:10.1371/journal.pone.0223914

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Open Access

Peer-reviewed

Research Article

Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome

Yosra Doghri ,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

* E-mail: yosra.doghri@oniris-nantes.fr

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯
Fabien Chetaneau,

Roles Investigation

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯
Moez Rhimi,

Roles Formal analysis, Software

Affiliation UMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Aicha Kriaa,

Roles Formal analysis

Affiliation UMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
Valérie Lalanne,

Roles Formal analysis

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯
Chantal Thorin,

Roles Data curation, Software, Validation

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯
Emmanuelle Maguin,

Roles Validation, Visualization

Affiliation UMR 1319 Micalis, INRA, Microbiota Interaction with Human and Animal Team (MIHA), AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
⨯
M. Yassine Mallem,

Roles Conceptualization, Investigation, Methodology, Supervision, Validation, Writing – original draft

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯
Jean-Claude Desfontis

Roles Project administration, Supervision, Validation, Visualization, Writing – review & editing

Affiliation UPSP NP3 (2017.B146), Nutrition, Pathophysiology and Pharmacology, Oniris, College of Veterinary Medicine, Food Sciences and Engineering, Atlanpôle—La Chantrerie, Route de Gachet, 5 BP, Nantes, France
⨯

Sildenafil citrate long-term treatment effects on cardiovascular reactivity in a SHR experimental model of metabolic syndrome

Yosra Doghri,
Fabien Chetaneau,
Moez Rhimi,
Aicha Kriaa,
Valérie Lalanne,
Chantal Thorin,
Emmanuelle Maguin,
M. Yassine Mallem,
Jean-Claude Desfontis

Published: November 7, 2019
https://doi.org/10.1371/journal.pone.0223914

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