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Open Access

Peer-reviewed

Research Article

Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

Xiaobin Xu ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editing

* E-mail: xiaobin.xu@regeneron.com

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America

http://orcid.org/0000-0002-4569-3133

⨯
Yu Huang,

Roles Conceptualization, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯
Hao Pan,

Roles Software, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯
Rosalynn Molden,

Roles Methodology, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯
Haibo Qiu,

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯
Thomas J. Daly,

Roles Supervision, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯
Ning Li

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliation Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
⨯

Quantitation and modeling of post-translational modifications in a therapeutic monoclonal antibody from single- and multiple-dose monkey pharmacokinetic studies using mass spectrometry

Xiaobin Xu,
Yu Huang,
Hao Pan,
Rosalynn Molden,
Haibo Qiu,
Thomas J. Daly,
Ning Li

x

Published: October 16, 2019
https://doi.org/10.1371/journal.pone.0223899

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Mannose
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