Gene editing of PKLR gene in human hematopoietic progenitors through 5’ and 3’ UTR modified TALEN mRNA

• Oscar Quintana-Bustamante ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: oscar.quintana@ciemat.es

  ¶‡ These authors equally contributed to this work and should be considered as first authors on this work.

  Affiliations Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), Madrid, Spain, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

  http://orcid.org/0000-0002-6869-7006

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• Sara Fañanas-Baquero ,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶‡ These authors equally contributed to this work and should be considered as first authors on this work.

  Affiliations Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), Madrid, Spain, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

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• Israel Orman,

  Roles Methodology

  Affiliations Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), Madrid, Spain, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

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• Raul Torres,

  Roles Resources

  Affiliations Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain, Instituto Josep Carreras, Barcelona, Spain

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• Philippe Duchateau,

  Roles Resources

  Affiliation CELLECTIS, Paris, France

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• Laurent Poirot,

  Roles Resources

  Affiliation CELLECTIS, Paris, France

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• Agnès Gouble,

  Roles Resources

  Affiliation CELLECTIS, Paris, France

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• Juan A. Bueren,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), Madrid, Spain, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

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• Jose C. Segovia

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  Affiliations Division of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIEMAT/CIBERER), Madrid, Spain, Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

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