Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer’s mouse model are associated with hippocampal synaptic deficits in an age-dependent manner

• Donald J. Joseph ,

  Contributed equally to this work with: Donald J. Joseph, Chunxia Liu

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• Chunxia Liu ,

  Contributed equally to this work with: Donald J. Joseph, Chunxia Liu

  Roles Data curation, Methodology, Writing – review & editing

  Affiliations Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Department of Anesthesiology, China-Japan Friendship Hospital, Beijing, China

  ⨯
• Jun Peng,

  Roles Data curation, Validation

  Affiliations Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Department of Anesthesiology, sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China

  ⨯
• Ge Liang,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  ⨯
• Huafeng Wei

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: Huafeng.wei@uphs.upenn.edu

  Affiliation Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

  http://orcid.org/0000-0002-5634-8378

  ⨯