Cell-free DNA levels of twins and sibling pairs indicate individuality and possible use as a personalized biomarker

Lamyaa Alghofaili; Hannah Almubarak; Khawlah Gassem; Syed S. Islam; Serdar Coskun; Namik Kaya; Bedri Karakas

doi:10.1371/journal.pone.0223470

Loading metrics

Open Access

Peer-reviewed

Research Article

Cell-free DNA levels of twins and sibling pairs indicate individuality and possible use as a personalized biomarker

Lamyaa Alghofaili ,

Contributed equally to this work with: Lamyaa Alghofaili, Hannah Almubarak

Roles Investigation, Resources

Affiliations Translational Cancer Research Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia, Alfaisal University Medical School, Riyadh, Saudi Arabia
⨯
Hannah Almubarak ,

Contributed equally to this work with: Lamyaa Alghofaili, Hannah Almubarak

Roles Investigation, Methodology, Writing – original draft

Current address: Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia

Affiliation Translational Cancer Research Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

http://orcid.org/0000-0001-5895-9968

⨯
Khawlah Gassem,

Roles Methodology

Affiliation Translational Cancer Research Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

http://orcid.org/0000-0001-7048-8839

⨯
Syed S. Islam,

Roles Methodology, Software

Affiliation Translational Cancer Research Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
⨯
Serdar Coskun,

Roles Methodology, Resources

Affiliation Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

http://orcid.org/0000-0002-7278-0902

⨯
Namik Kaya,

Roles Investigation

Affiliation Department of Genetics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
⨯
Bedri Karakas

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – review & editing

* E-mail: bedrik@yahoo.com

Affiliation Translational Cancer Research Section, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

http://orcid.org/0000-0002-5893-3212

⨯

Cell-free DNA levels of twins and sibling pairs indicate individuality and possible use as a personalized biomarker

Lamyaa Alghofaili,
Hannah Almubarak,
Khawlah Gassem,
Syed S. Islam,
Serdar Coskun,
Namik Kaya,
Bedri Karakas

Published: October 10, 2019
https://doi.org/10.1371/journal.pone.0223470

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Blood plasma
Is the Subject Area "Blood plasma" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Ovarian cancer
Is the Subject Area "Ovarian cancer" applicable to this article?

Thanks for your feedback.
Twins
Is the Subject Area "Twins" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Monozygotic twins
Is the Subject Area "Monozygotic twins" applicable to this article?

Thanks for your feedback.
Human genetics
Is the Subject Area "Human genetics" applicable to this article?

Thanks for your feedback.
Biomarkers
Is the Subject Area "Biomarkers" applicable to this article?

Thanks for your feedback.