Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection

Su Huang; Nick P. Goplen; Bibo Zhu; In Su Cheon; Youngmin Son; Zheng Wang; Chaofan Li; Qigang Dai; Li Jiang; Min Xiang; Eva M. Carmona; Robert Vassallo; Andrew H. Limper; Jie Sun

doi:10.1371/journal.pone.0223430

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Open Access

Peer-reviewed

Research Article

Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection

Su Huang,

Roles Investigation, Writing – original draft

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Nick P. Goplen,

Roles Data curation, Writing – original draft

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Bibo Zhu,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America

http://orcid.org/0000-0002-1187-4526

⨯
In Su Cheon,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Youngmin Son,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Zheng Wang,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Chaofan Li,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Qigang Dai,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Li Jiang,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Min Xiang,

Roles Investigation

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Eva M. Carmona,

Roles Conceptualization, Writing – review & editing

Affiliations Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America, Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Robert Vassallo,

Roles Conceptualization, Writing – review & editing

Affiliations Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America, Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Andrew H. Limper,

Roles Funding acquisition, Writing – review & editing

Affiliation Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America
⨯
Jie Sun

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: sun.jie@mayo.edu

Affiliations Thoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America, Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Rochester, Minnesota, United States of America

http://orcid.org/0000-0002-2347-4511

⨯

Macrophage PPAR-γ suppresses long-term lung fibrotic sequelae following acute influenza infection

Su Huang,
Nick P. Goplen,
Bibo Zhu,
In Su Cheon,
Youngmin Son,
Zheng Wang,
Chaofan Li,
Qigang Dai,
Li Jiang,
Min Xiang

Published: October 4, 2019
https://doi.org/10.1371/journal.pone.0223430

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Macrophages
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Respiratory infections
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Influenza
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Influenza viruses
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Pulmonary fibrosis
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Collagens
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Alveolar macrophages
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Gene expression
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