Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil

Giselle de Faria Romero Soldi; Isadora Coutinho Ribeiro; Cintia Mayumi Ahagon; Luana Portes Ozório Coelho; Gabriela Bastos Cabral; Giselle Ibette Silva López Lopes; João Leandro de Paula Ferreira; Luís Fernando de Macedo Brígido; on behalf of the Salvage Therapy Working Group

doi:10.1371/journal.pone.0223210

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Open Access

Peer-reviewed

Research Article

Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil

Giselle de Faria Romero Soldi,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil

http://orcid.org/0000-0001-5183-0117

⨯
Isadora Coutinho Ribeiro,

Roles Data curation, Methodology, Software, Visualization, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
Cintia Mayumi Ahagon,

Roles Data curation, Software, Visualization, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
Luana Portes Ozório Coelho,

Roles Methodology, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
Gabriela Bastos Cabral,

Roles Methodology, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
Giselle Ibette Silva López Lopes,

Roles Data curation, Software, Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
João Leandro de Paula Ferreira,

Roles Writing – review & editing

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
Luís Fernando de Macedo Brígido ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: lubrigido@gmail.com

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯
on behalf of the Salvage Therapy Working Group

¶Membership of the Salvage Therapy Working Group is provided in the Acknowledgments.

Affiliation Núcleo de Doenças de Vinculação Sanguínea ou Sexual, Laboratório de Retrovírus, Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brazil
⨯

Major drug resistance mutations to HIV-1 protease inhibitors (PI) among patients exposed to PI class failing antiretroviral therapy in São Paulo State, Brazil

Giselle de Faria Romero Soldi,
Isadora Coutinho Ribeiro,
Cintia Mayumi Ahagon,
Luana Portes Ozório Coelho,
Gabriela Bastos Cabral,
Giselle Ibette Silva López Lopes,
João Leandro de Paula Ferreira,
Luís Fernando de Macedo Brígido,
on behalf of the Salvage Therapy Working Group

Published: October 1, 2019
https://doi.org/10.1371/journal.pone.0223210

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Protease inhibitor therapy
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HIV-1
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Antiretroviral therapy
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Protease inhibitors
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