Discontinuous transcription of ribosomal DNA in human cells

Evgeny Smirnov; Peter Trosan; Joao Victor Cabral; Pavel Studeny; Sami Kereïche; Katerina Jirsova; Dušan Cmarko

doi:10.1371/journal.pone.0223030

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Open Access

Peer-reviewed

Research Article

Discontinuous transcription of ribosomal DNA in human cells

Evgeny Smirnov ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Validation, Writing – original draft

* E-mail: esmir@lf1.cuni.cz

Affiliation Laboratory of Cell Biology, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

http://orcid.org/0000-0002-5465-3846

⨯
Peter Trosan,

Roles Data curation, Methodology, Writing – review & editing

Affiliation Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

http://orcid.org/0000-0002-4836-0887

⨯
Joao Victor Cabral,

Roles Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

http://orcid.org/0000-0003-4898-5163

⨯
Pavel Studeny,

Roles Data curation, Writing – review & editing

Affiliation Ophthalmology Department of 3rd Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic
⨯
Sami Kereïche,

Roles Formal analysis, Software, Writing – review & editing

Affiliation Laboratory of Cell Biology, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
⨯
Katerina Jirsova,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Laboratory of the Biology and Pathology of the Eye, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
⨯
Dušan Cmarko

Roles Investigation, Supervision, Writing – review & editing

Affiliation Laboratory of Cell Biology, Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

http://orcid.org/0000-0002-7467-8565

⨯

Discontinuous transcription of ribosomal DNA in human cells

Evgeny Smirnov,
Peter Trosan,
Joao Victor Cabral,
Pavel Studeny,
Sami Kereïche,
Katerina Jirsova,
Dušan Cmarko

Published: March 2, 2020
https://doi.org/10.1371/journal.pone.0223030
See the preprint

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DNA transcription
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HeLa cells
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Gene expression
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Computer software
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Transfection
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Ribosomal RNA
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Cell signaling
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Cancers and neoplasms
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