Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types

Rena Okawa; Kazuma Kokomoto; Taichi Kitaoka; Takuo Kubota; Atsushi Watanabe; Takeshi Taketani; Toshimi Michigami; Keiichi Ozono; Kazuhiko Nakano

doi:10.1371/journal.pone.0222931

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Open Access

Peer-reviewed

Research Article

Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types

Rena Okawa ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Software, Visualization, Writing – original draft

* E-mail: rokawa@dent.osaka-u.ac.jp

Affiliation Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan

http://orcid.org/0000-0002-8634-209X

⨯
Kazuma Kokomoto,

Roles Data curation, Investigation, Software

Affiliation Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
⨯
Taichi Kitaoka,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Takuo Kubota,

Roles Formal analysis, Validation, Writing – review & editing

Affiliation Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Atsushi Watanabe,

Roles Data curation, Formal analysis, Supervision, Validation, Writing – review & editing

Affiliation Division of Clinical Genetics, Kanazawa University Hospital, Ishikawa, Japan
⨯
Takeshi Taketani,

Roles Formal analysis, Supervision, Validation, Writing – review & editing

Affiliation Department of Pediatrics, Shimane University Faculty of Medicine, Shimane, Japan
⨯
Toshimi Michigami,

Roles Formal analysis, Supervision, Validation, Writing – review & editing

Affiliation Department of Pediatric Nephrology and Metabolism, and Department of Bone and Mineral Research, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
⨯
Keiichi Ozono,

Roles Formal analysis, Supervision, Validation, Writing – review & editing

Affiliation Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
⨯
Kazuhiko Nakano

Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Validation, Writing – review & editing

Affiliation Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Osaka, Japan
⨯

Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types

Rena Okawa,
Kazuma Kokomoto,
Taichi Kitaoka,
Takuo Kubota,
Atsushi Watanabe,
Takeshi Taketani,
Toshimi Michigami,
Keiichi Ozono,
Kazuhiko Nakano

Published: October 10, 2019
https://doi.org/10.1371/journal.pone.0222931

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