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Open Access

Peer-reviewed

Research Article

Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT_1A receptor partial agonism and α₁-adrenoceptor antagonism

Alberto Montalbano,

Roles Investigation

Affiliation NEUROFARBA—Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università di Firenze, Firenze, Italia
⨯
Boris Mlinar,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation NEUROFARBA—Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università di Firenze, Firenze, Italia
⨯
Francesco Bonfiglio,

Roles Investigation

Affiliation NEUROFARBA—Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università di Firenze, Firenze, Italia
⨯
Lorenzo Polenzani,

Roles Conceptualization, Writing – review & editing

Affiliation Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A, S.Palomba-Pomezia (Roma), Italia
⨯
Maurizio Magnani,

Roles Conceptualization, Writing – review & editing

Affiliation Angelini RR&D (Research, Regulatory & Development), Angelini S.p.A, S.Palomba-Pomezia (Roma), Italia
⨯
Renato Corradetti

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

* E-mail: renato.corradetti@unifi.it

Affiliation NEUROFARBA—Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino, Università di Firenze, Firenze, Italia

http://orcid.org/0000-0002-2588-0484

⨯

Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT_1A receptor partial agonism and α₁-adrenoceptor antagonism

Alberto Montalbano,
Boris Mlinar,
Francesco Bonfiglio,
Lorenzo Polenzani,
Maurizio Magnani,
Renato Corradetti

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Published: September 26, 2019
https://doi.org/10.1371/journal.pone.0222855

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Neurons
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Serotonin receptors
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Serotonin
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Partial agonists
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Sleep
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Receptor antagonist therapy
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