PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils

Lei Yue; Min Yan; Michel L. Tremblay; Tong-Jun Lin; Hua Li; Ting Yang; Xia Song; Tianhong Xie; Zhongping Xie

doi:10.1371/journal.pone.0222753

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Open Access

Peer-reviewed

Research Article

PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils

Lei Yue ,

Contributed equally to this work with: Lei Yue, Min Yan

Roles Conceptualization, Data curation, Funding acquisition, Writing – original draft

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China
⨯
Min Yan ,

Contributed equally to this work with: Lei Yue, Min Yan

Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Department of Microbiology and Immunology, Kunming Medical University, Kunming, Yunnan, China
⨯
Michel L. Tremblay,

Roles Resources, Writing – review & editing

Affiliation Rosalind and Morris Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montréal, Quebec, Canada
⨯
Tong-Jun Lin,

Roles Funding acquisition, Resources

Affiliations Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
⨯
Hua Li,

Roles Formal analysis

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China
⨯
Ting Yang,

Roles Formal analysis

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China
⨯
Xia Song,

Roles Formal analysis

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China
⨯
Tianhong Xie,

Roles Formal analysis

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China
⨯
Zhongping Xie

Roles Funding acquisition, Supervision

* E-mail: xzp218@126.com

Affiliation The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China

http://orcid.org/0000-0001-5201-4373

⨯

PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils

Lei Yue,
Min Yan,
Michel L. Tremblay,
Tong-Jun Lin,
Hua Li,
Ting Yang,
Xia Song,
Tianhong Xie,
Zhongping Xie

Published: September 18, 2019
https://doi.org/10.1371/journal.pone.0222753

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Neutrophils
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Pseudomonas aeruginosa
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Phagocytosis
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Immune receptor signaling
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Nitric oxide
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Polymerase chain reaction
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STAT signaling
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