PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

Renata Senkerikova; Sona Frankova; Milan Jirsa; Miluse Kreidlova; Dusan Merta; Magdalena Neroldova; Klara Chmelova; Julius Spicak; Jan Sperl

doi:10.1371/journal.pone.0222609

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Peer-reviewed

Research Article

PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

Renata Senkerikova,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

Affiliations Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University, First Faculty of Medicine, Prague, Czech Republic
⨯
Sona Frankova,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Milan Jirsa,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations Charles University, First Faculty of Medicine, Prague, Czech Republic, Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Miluse Kreidlova,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Institute of Medical Biochemistry and Laboratory Diagnostics First Faculty of Medicine Charles University and General University Hospital in Prague, Prague, Czech Republic
⨯
Dusan Merta,

Roles Data curation, Formal analysis, Methodology, Software, Writing – original draft

Affiliation Anesthesiology, Resuscitation and Intensive Care Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Magdalena Neroldova,

Roles Methodology

Affiliations Charles University, First Faculty of Medicine, Prague, Czech Republic, Laboratory of Experimental Hepatology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Klara Chmelova,

Roles Writing – original draft

Affiliations Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University, First Faculty of Medicine, Prague, Czech Republic
⨯
Julius Spicak,

Roles Supervision, Writing – review & editing

Affiliation Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Jan Sperl

Roles Methodology, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: jan.sperl@ikem.cz

Affiliations Department of Hepatogastroenterology, Transplant Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Charles University, First Faculty of Medicine, Prague, Czech Republic

http://orcid.org/0000-0001-8619-2610

⨯

PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

Renata Senkerikova,
Sona Frankova,
Milan Jirsa,
Miluse Kreidlova,
Dusan Merta,
Magdalena Neroldova,
Klara Chmelova,
Julius Spicak,
Jan Sperl

Published: September 17, 2019
https://doi.org/10.1371/journal.pone.0222609

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Variant genotypes
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