RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

Shuyun Rao; Suraj Peri; Jens Hoffmann; Kathy Q. Cai; Bryan Harris; Michele Rhodes; Denise C. Connolly; Joseph R. Testa; David L. Wiest

doi:10.1371/journal.pone.0222392

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Open Access

Peer-reviewed

Research Article

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

Shuyun Rao ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft, Writing – review & editing

* E-mail: david.wiest@fccc.edu(DW); raoshuyun@gmail.com (SR)

Affiliation Center for Translational Medicine, Department of Surgery, George Washington University, Washington, DC, United States of America
⨯
Suraj Peri,

Roles Formal analysis

Affiliation Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
Jens Hoffmann,

Roles Investigation

Affiliation Experimental Pharmacology & Oncology Berlin-Buch GMBH, Berlin-Buch, Germany
⨯
Kathy Q. Cai,

Roles Data curation, Methodology

Affiliation Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
Bryan Harris,

Roles Data curation

Affiliation Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
Michele Rhodes,

Roles Data curation, Methodology

Affiliation Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
Denise C. Connolly,

Roles Formal analysis, Methodology

Affiliation Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
Joseph R. Testa,

Roles Writing – review & editing

Affiliation Cancer Biology Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America
⨯
David L. Wiest

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: david.wiest@fccc.edu(DW); raoshuyun@gmail.com (SR)

Affiliation Blood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, United States of America

http://orcid.org/0000-0002-0792-3188

⨯

RPL22L1 induction in colorectal cancer is associated with poor prognosis and 5-FU resistance

Shuyun Rao,
Suraj Peri,
Jens Hoffmann,
Kathy Q. Cai,
Bryan Harris,
Michele Rhodes,
Denise C. Connolly,
Joseph R. Testa,
David L. Wiest

Published: October 3, 2019
https://doi.org/10.1371/journal.pone.0222392

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Colorectal cancer
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Colon
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Cancer treatment
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Immunohistochemistry techniques
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Colon adenocarcinoma
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Nuclear staining
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Cell proliferation
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