Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury

Shani Zilberman-Itskovich; Ramzia Abu-Hamad; Rina Zarura; Marina Sova; Yafit Hachmo; Moshe Stark; Sara Neuman; Shimon Slavin; Shai Efrati

doi:10.1371/journal.pone.0222354

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Open Access

Peer-reviewed

Research Article

Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury

Shani Zilberman-Itskovich ,

Roles Investigation, Methodology, Project administration, Resources, Writing – original draft

* E-mail: shani.zilberman@mail.huji.ac.il

Affiliations Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

http://orcid.org/0000-0002-9289-4392

⨯
Ramzia Abu-Hamad,

Roles Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel
⨯
Rina Zarura,

Roles Data curation, Investigation

Affiliation Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel
⨯
Marina Sova,

Roles Data curation, Investigation

Affiliation Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel
⨯
Yafit Hachmo,

Roles Data curation, Investigation

Affiliation Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel
⨯
Moshe Stark,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel
⨯
Sara Neuman,

Roles Investigation, Methodology, Resources, Writing – review & editing

Affiliation Biotherapy International, The Center for Innovative Cancer Immunotherapy & Regenerative Medicine, Weizmann Center, Tel Aviv, Israel
⨯
Shimon Slavin,

Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Biotherapy International, The Center for Innovative Cancer Immunotherapy & Regenerative Medicine, Weizmann Center, Tel Aviv, Israel
⨯
Shai Efrati

Roles Conceptualization, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliations Nephrology Division, Assaf-Harofeh Medical Center, Zerifin, Israel, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
⨯

Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury

Shani Zilberman-Itskovich,
Ramzia Abu-Hamad,
Rina Zarura,
Marina Sova,
Yafit Hachmo,
Moshe Stark,
Sara Neuman,
Shimon Slavin,
Shai Efrati

Published: September 12, 2019
https://doi.org/10.1371/journal.pone.0222354

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Mesenchymal stem cells
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Complement system
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Kidneys
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Inflammation
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Macrophages
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Renal system
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