Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial

• Cristina Carter ,

  Contributed equally to this work with: Cristina Carter, Katherine V. Houser

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Katherine V. Houser ,

  Contributed equally to this work with: Cristina Carter, Katherine V. Houser

  Roles Formal analysis, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

  http://orcid.org/0000-0002-2147-186X

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• Galina V. Yamshchikov,

  Roles Conceptualization, Data curation, Project administration, Validation, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Abbie R. Bellamy,

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation The Emmes Corporation, Rockville, MD, United States of America

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• Jeanine May,

  Roles Data curation, Formal analysis, Validation, Writing – review & editing

  Affiliation The Emmes Corporation, Rockville, MD, United States of America

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• Mary E. Enama,

  Roles Conceptualization, Formal analysis, Project administration, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Uzma Sarwar,

  Roles Data curation, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Brenda Larkin,

  Roles Conceptualization, Funding acquisition, Resources, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Robert T. Bailer,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

  ⨯
• Richard Koup,

  Roles Conceptualization, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Grace L. Chen,

  Roles Project administration, Supervision, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Shital M. Patel,

  Roles Data curation, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Departments of Medicine and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States of America

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• Patricia Winokur,

  Roles Data curation, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United States of America

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• Robert Belshe,

  Roles Data curation, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Division of Infectious Diseases, Allergy and Immunology, Saint Louis University, St. Louis, MO, United States of America

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• Cornelia L. Dekker,

  Roles Data curation, Investigation, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Pediatrics (Infectious Diseases), Stanford University Medical Center, Stanford, CA, United States of America

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• Barney S. Graham,

  Roles Conceptualization, Funding acquisition, Resources, Validation, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

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• Julie E. Ledgerwood ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Ledgerwood@mail.nih.gov

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States of America

  http://orcid.org/0000-0002-2047-6052

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•  [ ... ],
• the VRC 703 study team

  ¶Membership of the VRC 703 study team can be found in the Acknowledgments.

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