Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease

J. Jasper Deuring; Meng Li; Wanlu Cao; Sunrui Chen; Wenshi Wang; Colin de Haar; C. Janneke van der Woude; Maikel Peppelenbosch

doi:10.1371/journal.pone.0221924

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Open Access

Peer-reviewed

Research Article

Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease

J. Jasper Deuring,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Meng Li,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Wanlu Cao,

Roles Conceptualization, Data curation, Investigation, Methodology

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Sunrui Chen,

Roles Investigation, Methodology

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Wenshi Wang,

Roles Investigation, Methodology

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Colin de Haar,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
C. Janneke van der Woude,

Roles Conceptualization, Data curation, Investigation, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
⨯
Maikel Peppelenbosch

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: m.peppelenbosch@erasmusmc.nl

Affiliation Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

http://orcid.org/0000-0001-9112-6028

⨯

Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease

J. Jasper Deuring,
Meng Li,
Wanlu Cao,
Sunrui Chen,
Wenshi Wang,
Colin de Haar,
C. Janneke van der Woude,
Maikel Peppelenbosch

Published: October 3, 2019
https://doi.org/10.1371/journal.pone.0221924

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