Cholinergic-like neurons carrying PSEN1 E280A mutation from familial Alzheimer’s disease reveal intraneuronal sAPPβ fragments accumulation, hyperphosphorylation of TAU, oxidative stress, apoptosis and Ca²⁺ dysregulation: Therapeutic implications

• Viviana Soto-Mercado,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), SIU Medellin, Medellin, Colombia

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• Miguel Mendivil-Perez,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), SIU Medellin, Medellin, Colombia

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• Carlos Velez-Pardo,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), SIU Medellin, Medellin, Colombia

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• Francisco Lopera,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), SIU Medellin, Medellin, Colombia

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• Marlene Jimenez-Del-Rio

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: marlene.jimenez@udea.edu.co

  Affiliation Neuroscience Research Group, Medical Research Institute, Faculty of Medicine, University of Antioquia (UdeA), SIU Medellin, Medellin, Colombia

  http://orcid.org/0000-0003-3477-2386

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