Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia

• Natanja Oosterom,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Erasmus MC, University Medical Center Rotterdam, Department of Clinical Chemistry, Rotterdam, The Netherlands

  http://orcid.org/0000-0001-9871-1887

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• Robert de Jonge,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliations VU Medical Center, Department of Clinical Chemistry, Amsterdam, The Netherlands, Academic Medical Center, Department of Clinical Chemistry, Amsterdam, The Netherlands

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• Desiree E. C. Smith,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation VU Medical Center, Department of Clinical Chemistry, Amsterdam, The Netherlands

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• Rob Pieters,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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• Wim J. E. Tissing,

  Roles Conceptualization, Funding acquisition, Methodology, Writing – review & editing

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Department of Pediatric Oncology, University of Groningen, Beatrix Children’s Hospital, University Medical Center Groningen, Groningen, The Netherlands

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• Marta Fiocco,

  Roles Formal analysis, Writing – review & editing

  Affiliations Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Mathematical Institute, Leiden University, Leiden, The Netherlands, Leiden University Medical Center, Department of Biomedical Data Sciences, Leiden, The Netherlands

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• Bertrand D. van Zelst,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Erasmus MC, University Medical Center Rotterdam, Department of Clinical Chemistry, Rotterdam, The Netherlands

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• Marry M. van den Heuvel-Eibrink,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

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• Sandra G. Heil

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: s.heil@erasmusmc.nl

  Affiliation Erasmus MC, University Medical Center Rotterdam, Department of Clinical Chemistry, Rotterdam, The Netherlands

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