Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model

Matthias Sammer; Katharina Teiluf; Stefanie Girst; Christoph Greubel; Judith Reindl; Katarina Ilicic; Dietrich W. M. Walsh; Michaela Aichler; Axel Walch; Stephanie E. Combs; Jan J. Wilkens; Günther Dollinger; Thomas E. Schmid

doi:10.1371/journal.pone.0221454

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Open Access

Peer-reviewed

Research Article

Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model

Matthias Sammer ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Writing – original draft, Writing – review & editing

* E-mail: matthias.sammer@unibw.de

Affiliation Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany

http://orcid.org/0000-0003-4017-3603

⨯
Katharina Teiluf,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliations Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, Institut für innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München (HMGU), Oberschleißheim, Germany, Deutches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany
⨯
Stefanie Girst,

Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – review & editing

Affiliation Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany
⨯
Christoph Greubel,

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany
⨯
Judith Reindl,

Roles Conceptualization, Investigation, Validation, Writing – review & editing

Affiliation Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany
⨯
Katarina Ilicic,

Roles Investigation, Methodology, Validation, Writing – review & editing

Affiliations Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, Institut für innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München (HMGU), Oberschleißheim, Germany, Deutches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany
⨯
Dietrich W. M. Walsh,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany, Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany
⨯
Michaela Aichler,

Roles Data curation, Investigation, Methodology

Affiliation Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Oberschleißheim, Germany
⨯
Axel Walch,

Roles Data curation, Investigation, Methodology

Affiliation Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Oberschleißheim, Germany
⨯
Stephanie E. Combs,

Roles Funding acquisition, Methodology, Project administration, Writing – review & editing

Affiliations Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, Institut für innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München (HMGU), Oberschleißheim, Germany, Deutches Konsortium für Translationale Krebsforschung (DKTK), Partner Site Munich, Munich, Germany
⨯
Jan J. Wilkens,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, Institut für innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München (HMGU), Oberschleißheim, Germany
⨯
Günther Dollinger,

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Institut für Angewandte Physik und Messtechnik (LRT2), Universität der Bundeswehr München, Neubiberg, Germany
⨯
Thomas E. Schmid

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliations Department of Radiation Oncology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany, Institut für innovative Radiotherapy (iRT), Department of Radiation Sciences (DRS), Helmholtz Zentrum München (HMGU), Oberschleißheim, Germany
⨯

Beam size limit for pencil minibeam radiotherapy determined from side effects in an in-vivo mouse ear model

Matthias Sammer,
Katharina Teiluf,
Stefanie Girst,
Christoph Greubel,
Judith Reindl,
Katarina Ilicic,
Dietrich W. M. Walsh,
Michaela Aichler,
Axel Walch,
Stephanie E. Combs

Published: September 4, 2019
https://doi.org/10.1371/journal.pone.0221454

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