Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting

Tristan M. Snowsill; Neil A. J. Ryan; Emma J. Crosbie; Ian M. Frayling; D. Gareth Evans; Chris J. Hyde

doi:10.1371/journal.pone.0221419

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Open Access

Peer-reviewed

Research Article

Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting

Tristan M. Snowsill ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – review & editing

* E-mail: t.m.snowsill@exeter.ac.uk

Affiliation Health Economics Group, University of Exeter Medical School, University of Exeter, Exeter, Devon, United Kingdom

http://orcid.org/0000-0001-7406-2819

⨯
Neil A. J. Ryan,

Roles Conceptualization, Validation, Writing – review & editing

Affiliations Division of Cancer Sciences, Faculty of Biology and Health, University of Manchester, Manchester, United Kingdom, Division of Evolution and Genomic Medicine, Faculty of Biology and Health, University of Manchester, Manchester, United Kingdom
⨯
Emma J. Crosbie,

Roles Conceptualization, Validation, Writing – review & editing

Affiliations Division of Cancer Sciences, Faculty of Biology and Health, University of Manchester, Manchester, United Kingdom, Directorate of Gynaecology, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom
⨯
Ian M. Frayling,

Roles Conceptualization, Validation, Writing – review & editing

Affiliation Inherited Tumour Syndromes Research Group, Institute of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom
⨯
D. Gareth Evans,

Roles Conceptualization, Validation, Writing – review & editing

Affiliations Division of Evolution and Genomic Medicine, Faculty of Biology and Health, University of Manchester, Manchester, United Kingdom, Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom
⨯
Chris J. Hyde

Roles Conceptualization, Validation, Writing – review & editing

Affiliation Exeter Test Group, University of Exeter Medical School, University of Exeter, Exeter, Devon, United Kingdom
⨯

Cost-effectiveness analysis of reflex testing for Lynch syndrome in women with endometrial cancer in the UK setting

Tristan M. Snowsill,
Neil A. J. Ryan,
Emma J. Crosbie,
Ian M. Frayling,
D. Gareth Evans,
Chris J. Hyde

Published: August 30, 2019
https://doi.org/10.1371/journal.pone.0221419

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Colorectal cancer
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Cost-effectiveness analysis
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Uterine cancer
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Methylation
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Immunohistochemistry techniques
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Hereditary nonpolyposis colorectal cancer
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Cancer epidemiology
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Reflexes
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