Multilevel regression modeling for aneuploidy classification and physical separation of maternal cell contamination facilitates the QF-PCR based analysis of common fetal aneuploidies

Predrag Noveski; Marija Terzic; Marija Vujovic; Maja Kuzmanovska; Emilija Sukarova Stefanovska; Dijana Plaseska-Karanfilska

doi:10.1371/journal.pone.0221227

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Peer-reviewed

Research Article

Multilevel regression modeling for aneuploidy classification and physical separation of maternal cell contamination facilitates the QF-PCR based analysis of common fetal aneuploidies

Predrag Noveski,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia
⨯
Marija Terzic,

Roles Data curation, Investigation

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia
⨯
Marija Vujovic,

Roles Data curation, Investigation

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia
⨯
Maja Kuzmanovska,

Roles Data curation, Investigation, Writing – review & editing

Current address: Laboratory for Virology and Molecular Diagnostics, Institute of Public Health, Skopje, Republic of Macedonia

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia
⨯
Emilija Sukarova Stefanovska,

Roles Investigation, Resources

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia
⨯
Dijana Plaseska-Karanfilska

Roles Conceptualization, Data curation, Investigation, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: dijana@manu.edu.mk

Affiliation Research Center for Genetic Engineering and Biotechnology “Georgi D. Efremov”, Macedonian Academy of Science and Arts, Skopje, Republic of Macedonia

http://orcid.org/0000-0001-8877-2416

⨯

Multilevel regression modeling for aneuploidy classification and physical separation of maternal cell contamination facilitates the QF-PCR based analysis of common fetal aneuploidies

Predrag Noveski,
Marija Terzic,
Marija Vujovic,
Maja Kuzmanovska,
Emilija Sukarova Stefanovska,
Dijana Plaseska-Karanfilska

Published: August 20, 2019
https://doi.org/10.1371/journal.pone.0221227

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Aneuploidy
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Polymerase chain reaction
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Amniotic fluid
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DNA isolation
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Sex chromosomes
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Trisomics
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Prenatal diagnosis
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Heterozygosity
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