Angiotensin II receptor blocker losartan exacerbates muscle damage and exhibits weak blood pressure-lowering activity in a dysferlin-null model of Limb-Girdle muscular dystrophy type 2B

• Zoe White ,

  Contributed equally to this work with: Zoe White, Nadia Milad

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: zoe.white@hli.ubc.ca (ZW); pascal.bernatchez@ubc.ca (PB)

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  http://orcid.org/0000-0002-1734-9896

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• Nadia Milad ,

  Contributed equally to this work with: Zoe White, Nadia Milad

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  http://orcid.org/0000-0002-1497-8224

  ⨯
• Arash Y. Tehrani,

  Roles Data curation

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  ⨯
• William Wei-Han Chen,

  Roles Data curation

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  http://orcid.org/0000-0002-9755-1428

  ⨯
• Graham Donen,

  Roles Data curation

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  ⨯
• Stephanie L. Sellers,

  Roles Data curation

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

  ⨯
• Pascal Bernatchez

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: zoe.white@hli.ubc.ca (ZW); pascal.bernatchez@ubc.ca (PB)

  Affiliations University of British Columbia (UBC) Department of Anesthesiology, Pharmacology & Therapeutics, Vancouver, Canada, UBC Centre for Heart Lung Innovation & St. Paul’s Hospital, Vancouver, Canada

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