Normal Saline solutions cause endothelial dysfunction through loss of membrane integrity, ATP release, and inflammatory responses mediated by P2X7R/p38 MAPK/MK2 signaling pathways

• Joyce Cheung-Flynn,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Bret D. Alvis,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Kyle M. Hocking,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

  http://orcid.org/0000-0002-3603-7185

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• Christy M. Guth,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Weifeng Luo,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Reid McCallister,

  Roles Formal analysis, Investigation

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Kalyan Chadalavada,

  Roles Formal analysis, Investigation

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Monica Polcz,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

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• Padmini Komalavilas ,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: padmini.komalavilas@vumc.org

  Affiliations Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

  http://orcid.org/0000-0002-3538-9488

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• Colleen M. Brophy

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, VA Tennessee Valley Healthcare System, Nashville, Tennessee, United States of America

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