Metabolomic profiling reveals salivary hypotaurine as a potential early detection marker for medication-related osteonecrosis of the jaw

• Wakako Yatsuoka ,

  Roles Conceptualization, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: wyatsuok@ncc.go.jp

  Affiliations Dental Division, National Cancer Center Hospital, Tsukiji, Chuo-ku, Japan, Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan

  http://orcid.org/0000-0002-6575-8264

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• Takao Ueno,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliation Dental Division, National Cancer Center Hospital, Tsukiji, Chuo-ku, Japan

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• Kanako Miyano,

  Roles Formal analysis, Methodology, Validation, Visualization

  Affiliation Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Japan

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• Yasuhito Uezono,

  Roles Supervision, Writing – review & editing

  Affiliations Division of Cancer Pathophysiology, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Japan, Division of Supportive Care Research, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, Tsukiji, Chuo-ku, Japan, Innovation Center for Supportive, Palliative and Psychosocial Care, National Cancer Center Hospital, Tsukiji, Chuo-ku, Japan

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• Ayame Enomoto,

  Roles Data curation, Software, Validation, Visualization

  Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka City, Yamagata, Japan

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• Miku Kaneko,

  Roles Conceptualization, Data curation, Formal analysis, Software, Validation

  Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka City, Yamagata, Japan

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• Sana Ota,

  Roles Data curation, Formal analysis, Software, Validation

  Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka City, Yamagata, Japan

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• Tomoyoshi Soga,

  Roles Supervision

  Affiliation Institute for Advanced Biosciences, Keio University, Tsuruoka City, Yamagata, Japan

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• Masahiro Sugimoto,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – review & editing

  Affiliations Institute for Advanced Biosciences, Keio University, Tsuruoka City, Yamagata, Japan, Research and Development Center for Minimally Invasive Therapies Health Promotion and Preemptive Medicine, Tokyo Medical University, Shinjuku, Japan

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• Toshikazu Ushijima

  Roles Supervision, Writing – review & editing

  Affiliations Course of Advanced Clinical Research of Cancer, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan, Division of Epigenomics, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Japan

  http://orcid.org/0000-0003-3405-7817

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