Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles

Yuuichi Arakawa; Kazumasa Yokoyama; Shinya Tasaki; Junichi Kato; Kosuke Nakashima; Michiyasu Takeyama; Atsushi Nakatani; Motohisa Suzuki

doi:10.1371/journal.pone.0220389

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Open Access

Peer-reviewed

Research Article

Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles

Yuuichi Arakawa,

Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Kazumasa Yokoyama,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Shinya Tasaki,

Roles Formal analysis, Investigation

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Junichi Kato,

Roles Formal analysis, Investigation

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Kosuke Nakashima,

Roles Formal analysis, Investigation

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Michiyasu Takeyama,

Roles Formal analysis, Investigation, Supervision

Affiliation Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Atsushi Nakatani,

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan
⨯
Motohisa Suzuki

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: motohisa.suzuki@takeda.com

Affiliation Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

http://orcid.org/0000-0001-8416-2733

⨯

Transgenic mice overexpressing miR-137 in the brain show schizophrenia-associated behavioral deficits and transcriptome profiles

Yuuichi Arakawa,
Kazumasa Yokoyama,
Shinya Tasaki,
Junichi Kato,
Kosuke Nakashima,
Michiyasu Takeyama,
Atsushi Nakatani,
Motohisa Suzuki

Published: July 30, 2019
https://doi.org/10.1371/journal.pone.0220389

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